Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

Increased glutathione (GSH) and thioredoxin (Trx) metabolism are mechanisms that are widely implicated in resistance of cancer cells to chemotherapy. The current study determined if simultaneous inhibition of GSH and Trx metabolism enhanced cell killing of human head and neck squamous cell carcinoma...

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Detalles Bibliográficos
Autores principales: Sobhakumari, Arya, Love-Homan, Laurie, Fletcher, Elise V. M., Martin, Sean M., Parsons, Arlene D., Spitz, Douglas R., Knudson, C. Michael, Simons, Andrean L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485193/
https://www.ncbi.nlm.nih.gov/pubmed/23118946
http://dx.doi.org/10.1371/journal.pone.0048175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485193/
https://www.ncbi.nlm.nih.gov/pubmed/23118946
http://dx.doi.org/10.1371/journal.pone.0048175

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