Structure-Based Engineering Increased the Catalytic Turnover Rate of a Novel Phenazine Prenyltransferase

Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto aromatic substrates in biosynthetic pathways of microbial secondary metabolites. Therefore, these enzymes contribute to the chemical diversity of natural products. Prenylation is frequently essential for the pharma...

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Detalles Bibliográficos
Autores principales: Zocher, Georg, Saleh, Orwah, Heim, Joel B., Herbst, Dominik A., Heide, Lutz, Stehle, Thilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485228/
https://www.ncbi.nlm.nih.gov/pubmed/23119011
http://dx.doi.org/10.1371/journal.pone.0048427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485228/
https://www.ncbi.nlm.nih.gov/pubmed/23119011
http://dx.doi.org/10.1371/journal.pone.0048427

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