Targeting 3-Phosphoinoside-Dependent Kinase-1 to Inhibit Insulin-Like Growth Factor-I Induced AKT and p70 S6 Kinase Activation in Breast Cancer Cells

Binding of IGF to IGF-IR activates PI3K to generate PIP3 which in turn recruits and activates proteins that contain a pleckstrin homology (PH) domain, including AKT and PDK1. PDK1 is highly expressed in breast tumor samples and breast cancer cell lines. Here we demonstrate that targeting PDK1 with t...

Descripción completa

Detalles Bibliográficos
Autores principales: Baxi, Sangita M., Tan, Wei, Murphy, Sean T., Smeal, Tod, Yin, Min-Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485233/
https://www.ncbi.nlm.nih.gov/pubmed/23119004
http://dx.doi.org/10.1371/journal.pone.0048402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485233/
https://www.ncbi.nlm.nih.gov/pubmed/23119004
http://dx.doi.org/10.1371/journal.pone.0048402

Ejemplares similares