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Targeting 3-Phosphoinoside-Dependent Kinase-1 to Inhibit Insulin-Like Growth Factor-I Induced AKT and p70 S6 Kinase Activation in Breast Cancer Cells

Binding of IGF to IGF-IR activates PI3K to generate PIP3 which in turn recruits and activates proteins that contain a pleckstrin homology (PH) domain, including AKT and PDK1. PDK1 is highly expressed in breast tumor samples and breast cancer cell lines. Here we demonstrate that targeting PDK1 with t...

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Detalles Bibliográficos
Autores principales:	Baxi, Sangita M., Tan, Wei, Murphy, Sean T., Smeal, Tod, Yin, Min-Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485233/ https://www.ncbi.nlm.nih.gov/pubmed/23119004 http://dx.doi.org/10.1371/journal.pone.0048402

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