FREQ-Seq: A Rapid, Cost-Effective, Sequencing-Based Method to Determine Allele Frequencies Directly from Mixed Populations

Understanding evolutionary dynamics within microbial populations requires the ability to accurately follow allele frequencies through time. Here we present a rapid, cost-effective method (FREQ-Seq) that leverages Illumina next-generation sequencing for localized, quantitative allele frequency detect...

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Detalles Bibliográficos
Autores principales: Chubiz, Lon M., Lee, Ming-Chun, Delaney, Nigel F., Marx, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485326/
https://www.ncbi.nlm.nih.gov/pubmed/23118913
http://dx.doi.org/10.1371/journal.pone.0047959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485326/
https://www.ncbi.nlm.nih.gov/pubmed/23118913
http://dx.doi.org/10.1371/journal.pone.0047959

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