CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways

The molecular mechanisms mediating CYLD tumor suppressor function appear to be manifold. Here, we demonstrated that, in contrast to the increased levels of pJNK, CYLD was decreased in a majority of melanoma cell lines and tissues examined. Exogenous expression of CYLD but not its catalytically defic...

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Detalles Bibliográficos
Autores principales: Ke, Hengning, Augustine, Christina K, Gandham, Vineela D, Jin, Jane Y, Tyler, Douglas S, Akiyama, Steven K, Hall, Russell P, Zhang, Jennifer Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485435/
https://www.ncbi.nlm.nih.gov/pubmed/22832488
http://dx.doi.org/10.1038/jid.2012.253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485435/
https://www.ncbi.nlm.nih.gov/pubmed/22832488
http://dx.doi.org/10.1038/jid.2012.253

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