Total Beta-Adrenoceptor Knockout Slows Conduction and Reduces Inducible Arrhythmias in the Mouse Heart

INTRODUCTION: Beta-adrenoceptors (β-AR) play an important role in the neurohumoral regulation of cardiac function. Three β-AR subtypes (β(1), β(2), β(3)) have been described so far. Total deficiency of these adrenoceptors (TKO) results in cardiac hypotrophy and negative inotropy. TKO represents a un...

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Detalles Bibliográficos
Autores principales: Stöckigt, Florian, Brixius, Klara, Lickfett, Lars, Andrié, René, Linhart, Markus, Nickenig, Georg, Schrickel, Jan Wilko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486811/
https://www.ncbi.nlm.nih.gov/pubmed/23133676
http://dx.doi.org/10.1371/journal.pone.0049203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486811/
https://www.ncbi.nlm.nih.gov/pubmed/23133676
http://dx.doi.org/10.1371/journal.pone.0049203

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