An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation

Several human diseases including neurodegenerative disorders and cancer are associated with abnormal accumulation and aggregation of misfolded proteins. Proteins with high tendency to aggregate include the p53 gene product, TAU and alpha synuclein. The potential toxicity of aberrantly folded protein...

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Detalles Bibliográficos
Autores principales: Kirilyuk, Alexander, Shimoji, Mika, Catania, Jason, Sahu, Geetaram, Pattabiraman, Nagarajan, Giordano, Antonio, Albanese, Christopher, Mocchetti, Italo, Toretsky, Jeffrey A., Uversky, Vladimir N., Avantaggiati, Maria Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486812/
https://www.ncbi.nlm.nih.gov/pubmed/23133622
http://dx.doi.org/10.1371/journal.pone.0048243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486812/
https://www.ncbi.nlm.nih.gov/pubmed/23133622
http://dx.doi.org/10.1371/journal.pone.0048243

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