3-Pyridyl Substituted Aliphatic Cycles as CYP11B2 Inhibitors: Aromaticity Abolishment of the Core Significantly Increased Selectivity over CYP1A2

Aldosterone synthase (CYP11B2) is a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone levels. On the basis of our previously identified lead compounds I–III, a series of 3-pyridinyl substituted aliphatic cycles were designed, synthesized...

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Detalles Bibliográficos
Autores principales: Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486838/
https://www.ncbi.nlm.nih.gov/pubmed/23133610
http://dx.doi.org/10.1371/journal.pone.0048048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486838/
https://www.ncbi.nlm.nih.gov/pubmed/23133610
http://dx.doi.org/10.1371/journal.pone.0048048

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