Dynamic Control of Selectivity in the Ubiquitination Pathway Revealed by an ASP to GLU Substitution in an Intra-Molecular Salt-Bridge Network

Ubiquitination relies on a subtle balance between selectivity and promiscuity achieved through specific interactions between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s). Here, we report how a single aspartic to glutamic acid substitution acts as a dynamic switch to tip the select...

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Detalles Bibliográficos
Autores principales: van Wijk, Sjoerd J. L., Melquiond, Adrien S. J., de Vries, Sjoerd J., Timmers, H. Th. Marc, Bonvin, Alexandre M. J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486841/
https://www.ncbi.nlm.nih.gov/pubmed/23133359
http://dx.doi.org/10.1371/journal.pcbi.1002754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486841/
https://www.ncbi.nlm.nih.gov/pubmed/23133359
http://dx.doi.org/10.1371/journal.pcbi.1002754

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