Niclosamide Is a Proton Carrier and Targets Acidic Endosomes with Broad Antiviral Effects

Viruses use a limited set of host pathways for infection. These pathways represent bona fide antiviral targets with low likelihood of viral resistance. We identified the salicylanilide niclosamide as a broad range antiviral agent targeting acidified endosomes. Niclosamide is approved for human use a...

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Detalles Bibliográficos
Autores principales: Jurgeit, Andreas, McDowell, Robert, Moese, Stefan, Meldrum, Eric, Schwendener, Reto, Greber, Urs F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486884/
https://www.ncbi.nlm.nih.gov/pubmed/23133371
http://dx.doi.org/10.1371/journal.ppat.1002976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486884/
https://www.ncbi.nlm.nih.gov/pubmed/23133371
http://dx.doi.org/10.1371/journal.ppat.1002976

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