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Niclosamide Is a Proton Carrier and Targets Acidic Endosomes with Broad Antiviral Effects
Viruses use a limited set of host pathways for infection. These pathways represent bona fide antiviral targets with low likelihood of viral resistance. We identified the salicylanilide niclosamide as a broad range antiviral agent targeting acidified endosomes. Niclosamide is approved for human use a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486884/ https://www.ncbi.nlm.nih.gov/pubmed/23133371 http://dx.doi.org/10.1371/journal.ppat.1002976 |