Topoisomerase II– and Condensin-Dependent Breakage of MEC1(ATR)-Sensitive Fragile Sites Occurs Independently of Spindle Tension, Anaphase, or Cytokinesis

Fragile sites are loci of recurrent chromosome breakage in the genome. They are found in organisms ranging from bacteria to humans and are implicated in genome instability, evolution, and cancer. In budding yeast, inactivation of Mec1, a homolog of mammalian ATR, leads to chromosome breakage at frag...

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Detalles Bibliográficos
Autores principales: Hashash, Nadia, Johnson, Anthony L., Cha, Rita S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486896/
https://www.ncbi.nlm.nih.gov/pubmed/23133392
http://dx.doi.org/10.1371/journal.pgen.1002978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486896/
https://www.ncbi.nlm.nih.gov/pubmed/23133392
http://dx.doi.org/10.1371/journal.pgen.1002978

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