Prion Pathogenesis Is Faithfully Reproduced in Cerebellar Organotypic Slice Cultures

Prions cause neurodegeneration in vivo, yet prion-infected cultured cells do not show cytotoxicity. This has hampered mechanistic studies of prion-induced neurodegeneration. Here we report that prion-infected cultured organotypic cerebellar slices (COCS) experienced progressive spongiform neurodegen...

Descripción completa

Detalles Bibliográficos
Autores principales: Falsig, Jeppe, Sonati, Tiziana, Herrmann, Uli S., Saban, Dino, Li, Bei, Arroyo, Karina, Ballmer, Boris, Liberski, Pawel P., Aguzzi, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486912/
https://www.ncbi.nlm.nih.gov/pubmed/23133383
http://dx.doi.org/10.1371/journal.ppat.1002985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486912/
https://www.ncbi.nlm.nih.gov/pubmed/23133383
http://dx.doi.org/10.1371/journal.ppat.1002985

Ejemplares similares