Biological Heart Rate Reduction Through Genetic Suppression of Gα(s) Protein in the Sinoatrial Node

BACKGROUND: Elevated heart rate represents an independent risk factor for cardiovascular outcome in patients with heart disease. In the sinoatrial node, rate increase is mediated by β(1) adrenoceptor mediated activation of the Gα(s) pathway. We hypothesized that genetic inactivation of the stimulato...

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Detalles Bibliográficos
Autores principales: Lugenbiel, Patrick, Bauer, Alexander, Kelemen, Kamilla, Schweizer, Patrick A., Becker, Rüdiger, Katus, Hugo A., Thomas, Dierk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487376/
https://www.ncbi.nlm.nih.gov/pubmed/23130123
http://dx.doi.org/10.1161/JAHA.111.000372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487376/
https://www.ncbi.nlm.nih.gov/pubmed/23130123
http://dx.doi.org/10.1161/JAHA.111.000372

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