Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration

Noradrenergic neurons in the locus coeruleus (LC) are significantly reduced in Parkinson’s disease (PD) and the LC exhibits neuropathological changes early in the disease process. It has been suggested that a loss of LC neurons can enhance the susceptibility of dopaminergic neurons to damage. To det...

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Detalles Bibliográficos
Autores principales: Szot, Patricia, Franklin, Allyn, Sikkema, Carl, Wilkinson, Charles W., Raskind, Murray A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487487/
https://www.ncbi.nlm.nih.gov/pubmed/23129999
http://dx.doi.org/10.3389/fphar.2012.00184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487487/
https://www.ncbi.nlm.nih.gov/pubmed/23129999
http://dx.doi.org/10.3389/fphar.2012.00184

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