A Single Native Ganglioside GM(1)-Binding Site Is Sufficient for Cholera Toxin To Bind to Cells and Complete the Intoxication Pathway

Cholera toxin (CT) from Vibrio cholerae is responsible for the majority of the symptoms of the diarrheal disease cholera. CT is a heterohexameric protein complex with a 240-residue A subunit and a pentameric B subunit of identical 103-residue B polypeptides. The A subunit is proteolytically cleaved...

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Detalles Bibliográficos
Autores principales: Jobling, Michael G., Yang, ZhiJie, Kam, Wendy R., Lencer, Wayne I., Holmes, Randall K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487775/
https://www.ncbi.nlm.nih.gov/pubmed/23111873
http://dx.doi.org/10.1128/mBio.00401-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487775/
https://www.ncbi.nlm.nih.gov/pubmed/23111873
http://dx.doi.org/10.1128/mBio.00401-12

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