Dopaminergic Neuronal Loss and Dopamine-Dependent Locomotor Defects in Fbxo7-Deficient Zebrafish

Recessive mutations in the F-box only protein 7 gene (FBXO7) cause PARK15, a Mendelian form of early-onset, levodopa-responsive parkinsonism with severe loss of nigrostriatal dopaminergic neurons. However, the function of the protein encoded by FBXO7, and the pathogenesis of PARK15 remain unknown. N...

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Detalles Bibliográficos
Autores principales: Zhao, Tianna, Zondervan-van der Linde, Herma, Severijnen, Lies-Anne, Oostra, Ben A., Willemsen, Rob, Bonifati, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487786/
https://www.ncbi.nlm.nih.gov/pubmed/23133663
http://dx.doi.org/10.1371/journal.pone.0048911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487786/
https://www.ncbi.nlm.nih.gov/pubmed/23133663
http://dx.doi.org/10.1371/journal.pone.0048911

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