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Late onset Li-Fraumeni Syndrome with bilateral breast cancer and other malignancies: case report and review of the literature
BACKGROUND: Li-Fraumeni-Syndrome (LFS) is an autosomal-dominant, inherited tumour predisposition syndrome associated with heterozygous germline mutations in the TP53 gene. Patients with LFS are at a high risk to develop early-onset breast cancer and multiple malignancies, among which sarcomas are th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487792/ https://www.ncbi.nlm.nih.gov/pubmed/22672556 http://dx.doi.org/10.1186/1471-2407-12-217 |