Late onset Li-Fraumeni Syndrome with bilateral breast cancer and other malignancies: case report and review of the literature

BACKGROUND: Li-Fraumeni-Syndrome (LFS) is an autosomal-dominant, inherited tumour predisposition syndrome associated with heterozygous germline mutations in the TP53 gene. Patients with LFS are at a high risk to develop early-onset breast cancer and multiple malignancies, among which sarcomas are th...

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Detalles Bibliográficos
Autores principales: Kast, Karin, Krause, Mechthild, Schuler, Markus, Friedrich, Katrin, Thamm, Barbara, Bier, Andrea, Distler, Wolfgang, Krüger, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487792/
https://www.ncbi.nlm.nih.gov/pubmed/22672556
http://dx.doi.org/10.1186/1471-2407-12-217

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