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Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease
BACKGROUND: Polycystic Kidney Disease (PKD) kidneys exhibit increased extracellular matrix (ECM) collagen expression and metalloproteinases (MMPs) activity. We investigated the role of these increases on cystic disease progression in PKD kidneys. METHODS: We examined the role of type I collagen (col...
Autores principales: | Liu, Bin, Li, Chenghai, Liu, Zijuan, Dai, Zonghan, Tao, Yunxia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487993/ https://www.ncbi.nlm.nih.gov/pubmed/22963260 http://dx.doi.org/10.1186/1471-2369-13-109 |
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