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Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression

BACKGROUND: Prevention of bladder cancer recurrence is a central challenge in the management of this highly prevalent disease. The histone deacetylase inhibitor valproic acid (sodium valproate) has anti-angiogenic properties and has been shown to decrease bladder cancer growth in model systems. We h...

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Detalles Bibliográficos
Autores principales: Byler, Timothy K, Leocadio, Dean, Shapiro, Oleg, Bratslavsky, Gennady, Stodgell, Christopher J, Wood, Ronald W, Messing, Edward M, Reeder, Jay E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487994/
https://www.ncbi.nlm.nih.gov/pubmed/22898175
http://dx.doi.org/10.1186/1471-2490-12-21