Metal and ligand binding to the HIV-RNase H active site are remotely monitored by Ile556

HIV-1 reverse transcriptase (RT) contains a C-terminal ribonuclease H (RH) domain on its p66 subunit that can be expressed as a stable, although inactive protein. Recent studies of several RH enzymes demonstrate that substrate binding plays a major role in the creation of the active site. In the abs...

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Detalles Bibliográficos
Autores principales: Zheng, Xunhai, Mueller, Geoffrey A., DeRose, Eugene F., London, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488238/
https://www.ncbi.nlm.nih.gov/pubmed/22941642
http://dx.doi.org/10.1093/nar/gks791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488238/
https://www.ncbi.nlm.nih.gov/pubmed/22941642
http://dx.doi.org/10.1093/nar/gks791

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