Cargando…
Metal and ligand binding to the HIV-RNase H active site are remotely monitored by Ile556
HIV-1 reverse transcriptase (RT) contains a C-terminal ribonuclease H (RH) domain on its p66 subunit that can be expressed as a stable, although inactive protein. Recent studies of several RH enzymes demonstrate that substrate binding plays a major role in the creation of the active site. In the abs...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488238/ https://www.ncbi.nlm.nih.gov/pubmed/22941642 http://dx.doi.org/10.1093/nar/gks791 |