A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

In human mitochondria the transcription machinery generates the RNA primers needed for initiation of DNA replication. A critical feature of the leading-strand origin of mitochondrial DNA replication is a CG-rich element denoted conserved sequence block II (CSB II). During transcription of CSB II, a...

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Detalles Bibliográficos
Autores principales: Wanrooij, Paulina H., Uhler, Jay P., Shi, Yonghong, Westerlund, Fredrik, Falkenberg, Maria, Gustafsson, Claes M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488243/
https://www.ncbi.nlm.nih.gov/pubmed/22965135
http://dx.doi.org/10.1093/nar/gks802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488243/
https://www.ncbi.nlm.nih.gov/pubmed/22965135
http://dx.doi.org/10.1093/nar/gks802

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