Cargando…

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

In human mitochondria the transcription machinery generates the RNA primers needed for initiation of DNA replication. A critical feature of the leading-strand origin of mitochondrial DNA replication is a CG-rich element denoted conserved sequence block II (CSB II). During transcription of CSB II, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wanrooij, Paulina H., Uhler, Jay P., Shi, Yonghong, Westerlund, Fredrik, Falkenberg, Maria, Gustafsson, Claes M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488243/ https://www.ncbi.nlm.nih.gov/pubmed/22965135 http://dx.doi.org/10.1093/nar/gks802

Ejemplares similares

Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element
por: Jemt, Elisabeth, et al.
Publicado: (2015)

A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL
por: Al-Behadili, Ali, et al.
Publicado: (2018)

Mitochondrial transcription termination factor 1 directs polar replication fork pausing
por: Shi, Yonghong, et al.
Publicado: (2016)

Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication
por: Obi, Ikenna, et al.
Publicado: (2020)

Single-molecule fluorescence studies on cotranscriptional G-quadruplex formation coupled with R-loop formation
por: Lim, Gunhyoung, et al.
Publicado: (2020)

The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis
por: Jemt, Elisabeth, et al.
Publicado: (2011)

The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA
por: Jiang, Kai, et al.
Publicado: (2021)

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells
por: Doimo, Mara, et al.
Publicado: (2023)

G-quadruplex recognition and remodeling by the FANCJ helicase
por: Wu, Colin G., et al.
Publicado: (2016)

Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA
por: Lopez, Christopher R., et al.
Publicado: (2017)

VID22 counteracts G-quadruplex-induced genome instability
por: Galati, Elena, et al.
Publicado: (2021)

G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase
por: Wallgren, Marcus, et al.
Publicado: (2016)

Quadruplex formation as a molecular switch to turn on intrinsically fluorescent nucleotide analogs
por: Johnson, John, et al.
Publicado: (2013)

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP
por: Budhathoki, Jagat B., et al.
Publicado: (2014)

ATP-dependent G-quadruplex unfolding by Bloom helicase exhibits low processivity
por: Budhathoki, Jagat B., et al.
Publicado: (2015)

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae
por: Piazza, Aurèle, et al.
Publicado: (2010)

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV
por: Madireddy, Advaitha, et al.
Publicado: (2016)

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
por: Zhou, Jia, et al.
Publicado: (2015)

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
por: Rizzo, Angela, et al.
Publicado: (2009)

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation
por: Lormand, Justin D., et al.
Publicado: (2013)

Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma
por: Nambiar, Mridula, et al.
Publicado: (2011)

Pif1 is essential for efficient replisome progression through lagging strand G-quadruplex DNA secondary structures
por: Dahan, Danielle, et al.
Publicado: (2018)

DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase
por: Douarre, Céline, et al.
Publicado: (2013)

Repair of O(6)-methylguanine adducts in human telomeric G-quadruplex DNA by O(6)-alkylguanine-DNA alkyltransferase
por: Hellman, Lance M., et al.
Publicado: (2014)

Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
por: Ketkar, Amit, et al.
Publicado: (2021)

Complementary roles of Pif1 helicase and single stranded DNA binding proteins in stimulating DNA replication through G-quadruplexes
por: Sparks, Melanie A, et al.
Publicado: (2019)

TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution
por: Kang, Hyun Je, et al.
Publicado: (2020)

Genetic instability associated with loop or stem–loop structures within transcription units can be independent of nucleotide excision repair
por: Burns, John A, et al.
Publicado: (2018)

Replisome bypass of transcription complexes and R-loops
por: Brüning, Jan-Gert, et al.
Publicado: (2020)

A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression
por: Deiana, Marco, et al.
Publicado: (2023)

Loop 1 modulates the fidelity of DNA polymerase λ
por: Bebenek, Katarzyna, et al.
Publicado: (2010)

Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis
por: Öz, Robin, et al.
Publicado: (2021)

The extruded non-template strand determines the architecture of R-loops
por: Carrasco-Salas, Yeraldinne, et al.
Publicado: (2019)

Genome-wide analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine at single-nucleotide resolution unveils reduced occurrence of oxidative damage at G-quadruplex sites
por: An, Jiao, et al.
Publicado: (2021)

Telomere shortening triggers a feedback loop to enhance end protection
por: Yang, Chia-Wei, et al.
Publicado: (2017)

R-loop formation by dCas9 is mutagenic in Saccharomyces cerevisiae
por: Laughery, Marian F, et al.
Publicado: (2019)

PARP1 associates with R-loops to promote their resolution and genome stability
por: Laspata, Natalie, et al.
Publicado: (2023)

Motif WFYY of human PrimPol is crucial to stabilize the incoming 3′-nucleotide during replication fork restart
por: Calvo, Patricia A, et al.
Publicado: (2021)

ADAR1 links R-loop homeostasis to ATR activation in replication stress response
por: Zhang, Biao, et al.
Publicado: (2023)

An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase
por: Windgassen, Tricia A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_69t1fh8ssj24cpgatks1qduahr