PALB2 self-interaction controls homologous recombination

PALB2 is essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks. Here, we report that the N-terminal coiled-coil motif of PALB2 regulates its self-association and homologous recombination. Monomeric PALB2 shows higher efficiency to b...

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Detalles Bibliográficos
Autores principales: Buisson, Rémi, Masson, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488246/
https://www.ncbi.nlm.nih.gov/pubmed/22941656
http://dx.doi.org/10.1093/nar/gks807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488246/
https://www.ncbi.nlm.nih.gov/pubmed/22941656
http://dx.doi.org/10.1093/nar/gks807

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