MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells

Trinucleotide repeat (TNR) expansions cause at least 17 heritable neurological diseases, including Huntington’s disease. Expansions are thought to arise from abnormal processing of TNR DNA by specific trans-acting proteins. For example, the DNA repair complex MutSβ (MSH2–MSH3 heterodimer) is require...

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Detalles Bibliográficos
Autores principales: Gannon, Anne-Marie M., Frizzell, Aisling, Healy, Evan, Lahue, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488247/
https://www.ncbi.nlm.nih.gov/pubmed/22941650
http://dx.doi.org/10.1093/nar/gks810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488247/
https://www.ncbi.nlm.nih.gov/pubmed/22941650
http://dx.doi.org/10.1093/nar/gks810

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