Cargando…

MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells

Trinucleotide repeat (TNR) expansions cause at least 17 heritable neurological diseases, including Huntington’s disease. Expansions are thought to arise from abnormal processing of TNR DNA by specific trans-acting proteins. For example, the DNA repair complex MutSβ (MSH2–MSH3 heterodimer) is require...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gannon, Anne-Marie M., Frizzell, Aisling, Healy, Evan, Lahue, Robert S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488247/ https://www.ncbi.nlm.nih.gov/pubmed/22941650 http://dx.doi.org/10.1093/nar/gks810

Ejemplares similares

The 26S proteasome drives trinucleotide repeat expansions
por: Concannon, Claire, et al.
Publicado: (2013)

MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions
por: Keogh, Norma, et al.
Publicado: (2017)

Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions
por: Debacker, Kim, et al.
Publicado: (2012)

Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion
por: Xu, Meng, et al.
Publicado: (2014)

AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair
por: Beaver, Jill M., et al.
Publicado: (2015)

Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells
por: Dastidar, Sumitava, et al.
Publicado: (2018)

The deoxyribose phosphate lyase of DNA polymerase β suppresses a processive DNA synthesis to prevent trinucleotide repeat instability
por: Lai, Yanhao, et al.
Publicado: (2018)

Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1
por: Xu, Meng, et al.
Publicado: (2013)

GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one
por: Halabi, Anasheh, et al.
Publicado: (2018)

A 5′, 8-cyclo-2′-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β
por: Xu, Meng, et al.
Publicado: (2014)

Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair
por: Elez, Marina, et al.
Publicado: (2012)

The sliding clamp tethers the endonuclease domain of MutL to DNA
por: Pillon, Monica C., et al.
Publicado: (2015)

SLX4 dampens MutSα-dependent mismatch repair
por: Guervilly, Jean-Hugues, et al.
Publicado: (2022)

Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS
por: LeBlanc, Sharonda J, et al.
Publicado: (2018)

Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity
por: Gordon, Alasdair J.E., et al.
Publicado: (2014)

MutL binds to 3′ resected DNA ends and blocks DNA polymerase access
por: Borsellini, Alessandro, et al.
Publicado: (2022)

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex
por: Kim, Yoori, et al.
Publicado: (2019)

Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA
por: Cristóvão, Michele, et al.
Publicado: (2012)

Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation
por: Groothuizen, Flora S., et al.
Publicado: (2013)

Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding
por: Bruekner, Susanne R, et al.
Publicado: (2023)

The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension
por: Witte, Scott J, et al.
Publicado: (2023)

Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation
por: Shen, Mengyu, et al.
Publicado: (2018)

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair
por: Mardenborough, Yannicka S N, et al.
Publicado: (2019)

Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery
por: Houseley, Jonathan, et al.
Publicado: (2011)

Mph1 requires mismatch repair-independent and -dependent functions of MutSα to regulate crossover formation during homologous recombination repair
por: Tay, Ye Dee, et al.
Publicado: (2010)

MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity
por: Margara, Lucía M., et al.
Publicado: (2016)

Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania
por: Mukherjee, Angana, et al.
Publicado: (2011)

RNA–DNA hybrids promote the expansion of Friedreich's ataxia (GAA)(n) repeats via break-induced replication
por: Neil, Alexander J, et al.
Publicado: (2018)

RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility
por: Frizzell, Aisling, et al.
Publicado: (2014)

Disease-associated CAG·CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion
por: Gomes-Pereira, Mário, et al.
Publicado: (2014)

Histone deacetylase complexes as caretakers of genome stability
por: Lahue, Robert, et al.
Publicado: (2012)

Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers
por: Rastokina, Anastasia, et al.
Publicado: (2023)

Functional characterization and architecture of recombinant yeast SWR1 histone exchange complex
por: Lin, Chia-Liang, et al.
Publicado: (2017)

The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2
por: Geng, Anke, et al.
Publicado: (2020)

Histone variant Htz1 promotes histone H3 acetylation to enhance nucleotide excision repair in Htz1 nucleosomes
por: Yu, Yachuan, et al.
Publicado: (2013)

OGT restrains the expansion of DNA damage signaling
por: Chen, Qiang, et al.
Publicado: (2016)

Complex repeat structure promotes hyper-amplification and amplicon evolution through rolling-circle replication
por: Watanabe, Takaaki, et al.
Publicado: (2018)

DNA expansions generated by human Polµ on iterative sequences
por: Aza, Ana, et al.
Publicado: (2013)

Combinatorial recognition of a complex telomere repeat sequence by the Candida parapsilosis Cdc13AB heterodimer
por: Steinberg-Neifach, Olga, et al.
Publicado: (2015)

Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin
por: Casas-Delucchi, Corella S., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4duu81ic31t3h4tb2g1hlpa5mk