Nucleosome dynamics: HMGB1 relaxes canonical nucleosome structure to facilitate estrogen receptor binding

High mobility group protein 1 (HMGB1) interacts with DNA and chromatin to influence the regulation of transcription, DNA repair and recombination. We show that HMGB1 alters the structure and stability of the canonical nucleosome (N) in a nonenzymatic, ATP-independent manner. Although estrogen recept...

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Detalles Bibliográficos
Autores principales: Joshi, Sachindra R., Sarpong, Yaw C., Peterson, Ronald C., Scovell, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488250/
https://www.ncbi.nlm.nih.gov/pubmed/22941653
http://dx.doi.org/10.1093/nar/gks815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488250/
https://www.ncbi.nlm.nih.gov/pubmed/22941653
http://dx.doi.org/10.1093/nar/gks815

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