The antibiotic Furvina® targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias

Furvina®, also denominated G1 (MW 297), is a synthetic nitrovinylfuran [2-bromo-5-(2-bromo-2-nitrovinyl)-furan] antibiotic with a broad antimicrobial spectrum. An ointment (Dermofural®) containing G1 as the only active principle is currently marketed in Cuba and successfully used to treat dermatolog...

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Detalles Bibliográficos
Autores principales: Fabbretti, Attilio, Brandi, Letizia, Petrelli, Dezemona, Pon, Cynthia L., Castañedo, Nilo R., Medina, Ricardo, Gualerzi, Claudio O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488254/
https://www.ncbi.nlm.nih.gov/pubmed/22941660
http://dx.doi.org/10.1093/nar/gks822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488254/
https://www.ncbi.nlm.nih.gov/pubmed/22941660
http://dx.doi.org/10.1093/nar/gks822

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