X-ray structure of the fourth type of archaeal tRNA splicing endonuclease: insights into the evolution of a novel three-unit composition and a unique loop involved in broad substrate specificity

Cleavage of introns from precursor transfer RNAs (tRNAs) by tRNA splicing endonuclease (EndA) is essential for tRNA maturation in Archaea and Eukarya. In the past, archaeal EndAs were classified into three types (α′(2), α(4 )and α(2)β(2)) according to subunit composition. Recently, we have identifie...

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Detalles Bibliográficos
Autores principales: Hirata, Akira, Fujishima, Kosuke, Yamagami, Ryota, Kawamura, Takuya, Banfield, Jillian F., Kanai, Akio, Hori, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488258/
https://www.ncbi.nlm.nih.gov/pubmed/22941657
http://dx.doi.org/10.1093/nar/gks826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488258/
https://www.ncbi.nlm.nih.gov/pubmed/22941657
http://dx.doi.org/10.1093/nar/gks826

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