Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation via the base excision repair pathway. TDG excises the mismatched base from G:X mismatches, where X is uracil, thymine or 5-hydroxymethyluracil (5hmU). These are, respectively, the deamination products of cytosine,...

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Detalles Bibliográficos
Autores principales: Hashimoto, Hideharu, Hong, Samuel, Bhagwat, Ashok S., Zhang, Xing, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488261/
https://www.ncbi.nlm.nih.gov/pubmed/22962365
http://dx.doi.org/10.1093/nar/gks845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488261/
https://www.ncbi.nlm.nih.gov/pubmed/22962365
http://dx.doi.org/10.1093/nar/gks845

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