The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain

BACKGROUND: Oxidized linoleic acid metabolites (OLAMs) are a class of endogenous agonists to the transient receptor potential V1 (TRPV1) receptor. Although TRPV1 mediates inflammatory heat hyperalgesia, it is not known if the OLAMs contribute to the peripheral activation of this receptor during tiss...

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Detalles Bibliográficos
Autores principales: Ruparel, Shivani, Green, Dustin, Chen, Paul, Hargreaves, Kenneth M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488501/
https://www.ncbi.nlm.nih.gov/pubmed/23006841
http://dx.doi.org/10.1186/1744-8069-8-73

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488501/
https://www.ncbi.nlm.nih.gov/pubmed/23006841
http://dx.doi.org/10.1186/1744-8069-8-73

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