Cargando…

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

BACKGROUND: Multiple myeloma (MM) is at present an incurable malignancy, characterized by apoptosis-resistant tumor cells. Interferon (IFN) treatment sensitizes MM cells to Fas-induced apoptosis and is associated with an increased activation of Signal transducer and activator of transcription (Stat)...

Descripción completa

Detalles Bibliográficos
Autores principales: Dimberg, Lina Y, Dimberg, Anna, Ivarsson, Karolina, Fryknäs, Mårten, Rickardson, Linda, Tobin, Gerard, Ekman, Simon, Larsson, Rolf, Gullberg, Urban, Nilsson, Kenneth, Öberg, Fredrik, Wiklund, Helena Jernberg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488543/
https://www.ncbi.nlm.nih.gov/pubmed/22838736
http://dx.doi.org/10.1186/1471-2407-12-318