Secreted phospholipase A(2)-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding

BACKGROUND: Activation of microglia, the primary component of the innate immune response in the brain, is a hallmark of neuroinflammation in neurodegenerative disorders, including Alzheimer’s disease (AD) and other pathological conditions such as stroke or CNS infection. In response to a variety of...

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Detalles Bibliográficos
Autores principales: Martín, Rubén, Cordova, Claudia, Nieto, Maria L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488565/
https://www.ncbi.nlm.nih.gov/pubmed/22747893
http://dx.doi.org/10.1186/1742-2094-9-154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488565/
https://www.ncbi.nlm.nih.gov/pubmed/22747893
http://dx.doi.org/10.1186/1742-2094-9-154

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