Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathways

BACKGROUND: Expression of active c-Abl in adult mouse forebrain neurons in the AblPP/tTA mice resulted in severe neurodegeneration, particularly in the CA1 region of the hippocampus. Neuronal loss was preceded and accompanied by substantial microgliosis and astrocytosis. In contrast, expression of c...

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Detalles Bibliográficos
Autores principales: Schlatterer, Sarah D, Suh, Hyeon-sook, Conejero-Goldberg, Concepcion, Chen, Shufen, Acker, Christopher M, Lee, Sunhee C, Davies, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488571/
https://www.ncbi.nlm.nih.gov/pubmed/22938163
http://dx.doi.org/10.1186/1742-2094-9-208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488571/
https://www.ncbi.nlm.nih.gov/pubmed/22938163
http://dx.doi.org/10.1186/1742-2094-9-208

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