A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability

BACKGROUND: Fascin-1 is an actin crosslinking protein that is important for the assembly of cell protrusions in neurons, skeletal and smooth muscle, fibroblasts, and dendritic cells. Although absent from most normal adult epithelia, fascin-1 is upregulated in many human carcinomas, and is associated...

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Detalles Bibliográficos
Autores principales: Jayo, Asier, Parsons, Maddy, Adams, Josephine C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488970/
https://www.ncbi.nlm.nih.gov/pubmed/22883572
http://dx.doi.org/10.1186/1741-7007-10-72

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488970/
https://www.ncbi.nlm.nih.gov/pubmed/22883572
http://dx.doi.org/10.1186/1741-7007-10-72

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