Sigma-1 Receptor Agonists Directly Inhibit Na(V)1.2/1.4 Channels

(+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+)-SKF 10047 inhibits K(+), Na(+) and Ca2+ channels via sigma-1 receptor activation. We found that (+)-SKF 10047 inhibited Na(V)1.2...

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Detalles Bibliográficos
Autores principales: Gao, Xiao-Fei, Yao, Jin-Jing, He, Yan-Lin, Hu, Changlong, Mei, Yan-Ai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489664/
https://www.ncbi.nlm.nih.gov/pubmed/23139844
http://dx.doi.org/10.1371/journal.pone.0049384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489664/
https://www.ncbi.nlm.nih.gov/pubmed/23139844
http://dx.doi.org/10.1371/journal.pone.0049384

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