"Flagellated" cancer cells propel anti-tumor immunity

The use of innate immune receptor agonists in cancer therapies has suffered from many drawbacks. Our recent observations suggest that some of these hurdles can be overcome by introducing flagellin into tumor cells to promote tumor antigen presentation by dendritic cells (DCs) and simultaneously trig...

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Detalles Bibliográficos
Autores principales: Garaude, Johan, Blander, J. Magarian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489752/
https://www.ncbi.nlm.nih.gov/pubmed/23162764
http://dx.doi.org/10.4161/onci.20305
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author Garaude, Johan
Blander, J. Magarian
author_facet Garaude, Johan
Blander, J. Magarian
author_sort Garaude, Johan
collection PubMed
description The use of innate immune receptor agonists in cancer therapies has suffered from many drawbacks. Our recent observations suggest that some of these hurdles can be overcome by introducing flagellin into tumor cells to promote tumor antigen presentation by dendritic cells (DCs) and simultaneously trigger two types of pattern recognition receptors (PRRs).
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spelling pubmed-34897522012-11-16 "Flagellated" cancer cells propel anti-tumor immunity Garaude, Johan Blander, J. Magarian Oncoimmunology Author's View The use of innate immune receptor agonists in cancer therapies has suffered from many drawbacks. Our recent observations suggest that some of these hurdles can be overcome by introducing flagellin into tumor cells to promote tumor antigen presentation by dendritic cells (DCs) and simultaneously trigger two types of pattern recognition receptors (PRRs). Landes Bioscience 2012-09-01 /pmc/articles/PMC3489752/ /pubmed/23162764 http://dx.doi.org/10.4161/onci.20305 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Garaude, Johan
Blander, J. Magarian
"Flagellated" cancer cells propel anti-tumor immunity
title "Flagellated" cancer cells propel anti-tumor immunity
title_full "Flagellated" cancer cells propel anti-tumor immunity
title_fullStr "Flagellated" cancer cells propel anti-tumor immunity
title_full_unstemmed "Flagellated" cancer cells propel anti-tumor immunity
title_short "Flagellated" cancer cells propel anti-tumor immunity
title_sort "flagellated" cancer cells propel anti-tumor immunity
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489752/
https://www.ncbi.nlm.nih.gov/pubmed/23162764
http://dx.doi.org/10.4161/onci.20305
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