Class I histone deacetylase inhibition is a novel mechanism to target regulatory T cells in immunotherapy

Regulatory T cells (Tregs) represent a major obstacle of cancer immunotherapy. We reviewed here our discovery that Class I histone deacetylase (HDAC) inhibition can functionally target Tregs and help break the immune tolerance. We also discuss the effects of different classes of HDAC inhibitors on T...

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Detalles Bibliográficos
Autores principales: Shen, Li, Pili, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489755/
https://www.ncbi.nlm.nih.gov/pubmed/23162767
http://dx.doi.org/10.4161/onci.20306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489755/
https://www.ncbi.nlm.nih.gov/pubmed/23162767
http://dx.doi.org/10.4161/onci.20306

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