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Class I histone deacetylase inhibition is a novel mechanism to target regulatory T cells in immunotherapy
Regulatory T cells (Tregs) represent a major obstacle of cancer immunotherapy. We reviewed here our discovery that Class I histone deacetylase (HDAC) inhibition can functionally target Tregs and help break the immune tolerance. We also discuss the effects of different classes of HDAC inhibitors on T...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489755/ https://www.ncbi.nlm.nih.gov/pubmed/23162767 http://dx.doi.org/10.4161/onci.20306 |