How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis

We recently reported that anti-inflammatory macrophages contribute to the initiation of colorectal carcinogenesis in IBD patients by inducing epithelial-mesenchymal-transition associated alterations in colonic epithelial cells. In this process, TGFβ1 dependent upregulation of the adhesion molecule L...

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Detalles Bibliográficos
Autores principales: Sebens, Susanne, Schäfer, Heiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489756/
https://www.ncbi.nlm.nih.gov/pubmed/23162768
http://dx.doi.org/10.4161/onci.19949
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author Sebens, Susanne
Schäfer, Heiner
author_facet Sebens, Susanne
Schäfer, Heiner
author_sort Sebens, Susanne
collection PubMed
description We recently reported that anti-inflammatory macrophages contribute to the initiation of colorectal carcinogenesis in IBD patients by inducing epithelial-mesenchymal-transition associated alterations in colonic epithelial cells. In this process, TGFβ1 dependent upregulation of the adhesion molecule L1CAM is one key event, paving the way to colitis associated tumorigenesis and metastatic spread.
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spelling pubmed-34897562012-11-16 How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis Sebens, Susanne Schäfer, Heiner Oncoimmunology Author's View We recently reported that anti-inflammatory macrophages contribute to the initiation of colorectal carcinogenesis in IBD patients by inducing epithelial-mesenchymal-transition associated alterations in colonic epithelial cells. In this process, TGFβ1 dependent upregulation of the adhesion molecule L1CAM is one key event, paving the way to colitis associated tumorigenesis and metastatic spread. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489756/ /pubmed/23162768 http://dx.doi.org/10.4161/onci.19949 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sebens, Susanne
Schäfer, Heiner
How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis
title How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis
title_full How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis
title_fullStr How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis
title_full_unstemmed How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis
title_short How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis
title_sort how two sites of inflammation promote carcinogenesis: the role of macrophages in inflammation associated carcinogenesis
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489756/
https://www.ncbi.nlm.nih.gov/pubmed/23162768
http://dx.doi.org/10.4161/onci.19949
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