Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody

Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). We recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specific mAb, resulting in increased ADCC against cancer cells.

Detalles Bibliográficos
Autores principales: Houot, Roch, Kohrt, Holbrook, Levy, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489758/
https://www.ncbi.nlm.nih.gov/pubmed/23162770
http://dx.doi.org/10.4161/onci.19974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489758/
https://www.ncbi.nlm.nih.gov/pubmed/23162770
http://dx.doi.org/10.4161/onci.19974

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