Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody

Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). We recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specific mAb, resulting in increased ADCC against cancer cells.

Detalles Bibliográficos
Autores principales: Houot, Roch, Kohrt, Holbrook, Levy, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489758/
https://www.ncbi.nlm.nih.gov/pubmed/23162770
http://dx.doi.org/10.4161/onci.19974
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author Houot, Roch
Kohrt, Holbrook
Levy, Ron
author_facet Houot, Roch
Kohrt, Holbrook
Levy, Ron
author_sort Houot, Roch
collection PubMed
description Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). We recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specific mAb, resulting in increased ADCC against cancer cells.
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spelling pubmed-34897582012-11-16 Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody Houot, Roch Kohrt, Holbrook Levy, Ron Oncoimmunology Author's View Monoclonal antibodies (mAb) induce tumor regression through antibody-dependant cellular cytotoxicity (ADCC). We recently showed that an agonistic anti-CD137 mAb stimulates natural killer (NK) cells which have been activated by a tumor-specific mAb, resulting in increased ADCC against cancer cells. Landes Bioscience 2012-09-01 /pmc/articles/PMC3489758/ /pubmed/23162770 http://dx.doi.org/10.4161/onci.19974 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Houot, Roch
Kohrt, Holbrook
Levy, Ron
Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
title Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
title_full Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
title_fullStr Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
title_full_unstemmed Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
title_short Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
title_sort boosting antibody-dependant cellular cytotoxicity against tumor cells with a cd137 stimulatory antibody
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489758/
https://www.ncbi.nlm.nih.gov/pubmed/23162770
http://dx.doi.org/10.4161/onci.19974
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AT levyron boostingantibodydependantcellularcytotoxicityagainsttumorcellswithacd137stimulatoryantibody

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