Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrP(Sc) Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC

Different transmissible spongiform encephalopathy (TSE)-associated forms of prion protein (e.g. PrP(Sc)) can vary markedly in ultrastructure and biochemical characteristics, but each is propagated in the host. PrP(Sc) propagation involves conversion from its normal isoform, PrP(C), by a seeded or te...

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Detalles Bibliográficos
Autores principales: Vascellari, Sarah, Orrù, Christina D., Hughson, Andrew G., King, Declan, Barron, Rona, Wilham, Jason M., Baron, Gerald S., Race, Brent, Pani, Alessandra, Caughey, Byron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489776/
https://www.ncbi.nlm.nih.gov/pubmed/23139828
http://dx.doi.org/10.1371/journal.pone.0048969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489776/
https://www.ncbi.nlm.nih.gov/pubmed/23139828
http://dx.doi.org/10.1371/journal.pone.0048969

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