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In silico 3D structure analysis accelerates the solution of a real viral structure and antibodies docking mechanism

Norwalk virus (NoV) is responsible for most outbreaks of non-bacterial gastroenteritis. NoV is genetically diverse and show antigenically variable. Recently, we produced a monoclonal antibody called 5B-18 that reacts broadly with NoV genogroup II (GII). We suspected the 5B-18 binds to a conformation...

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Detalles Bibliográficos
Autores principales: Miki, Motohiro, Katayama, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490151/
https://www.ncbi.nlm.nih.gov/pubmed/23133439
http://dx.doi.org/10.3389/fmicb.2012.00387