3D structure analysis of PAKs: A clue to the rational design for affinity reagents and blockers

The p21-activated kinase (PAK) family plays a versatile role in cell signaling by forming a hub of interactions. PAKs bind the GTPases like RAC and CDC42. Their proline-rich motifs bind SH3 adaptor proteins such as PIX and NCK. PAKs display nuclear localization signal sites and a potential Integrin...

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Detalles Bibliográficos
Autores principales: Jha, Ramesh K., Strauss, Charlie E.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490965/
https://www.ncbi.nlm.nih.gov/pubmed/23162739
http://dx.doi.org/10.4161/cl.21883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490965/
https://www.ncbi.nlm.nih.gov/pubmed/23162739
http://dx.doi.org/10.4161/cl.21883

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