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BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions

DNA methylation is an important epigenetic modification involved in gene regulation, which can now be measured using whole-genome bisulfite sequencing. However, cost, complexity of the data, and lack of comprehensive analytical tools are major challenges that keep this technology from becoming widel...

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Detalles Bibliográficos
Autores principales: Hansen, Kasper D, Langmead, Benjamin, Irizarry, Rafael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491411/
https://www.ncbi.nlm.nih.gov/pubmed/23034175
http://dx.doi.org/10.1186/gb-2012-13-10-r83