Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

BACKGROUND: Aberrant CpG island promoter DNA hypermethylation is frequently observed in cancer and is believed to contribute to tumor progression by silencing the expression of tumor suppressor genes. Previously, we observed that promoter hypermethylation in breast cancer reflects cell lineage rathe...

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Detalles Bibliográficos
Autores principales: Sproul, Duncan, Kitchen, Robert R, Nestor, Colm E, Dixon, J Michael, Sims, Andrew H, Harrison, David J, Ramsahoye, Bernard H, Meehan, Richard R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491412/
https://www.ncbi.nlm.nih.gov/pubmed/23034185
http://dx.doi.org/10.1186/gb-2012-13-10-r84

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491412/
https://www.ncbi.nlm.nih.gov/pubmed/23034185
http://dx.doi.org/10.1186/gb-2012-13-10-r84

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